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KMID : 1202020080010010017
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Journal of Korean Thyroid Association
2008 Volume.1 No. 1 p.17 ~ p.23
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Prognostic Factors Correlated with Cancer Specitic Survival and Disease-free Survival of Papikkary Thyroid Carcinoma in Korea
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Kim Won-Gu
Kim Tae-Yong
Lee Jeong-Hyun
Kim Eui-Young
Gong Gyung-Yup
Ryu Jin-Sook
Kim Jung-Min
Kim Won-Bae
Yoon Jong-Ho
Shong Young-Kee
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Abstract
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Background and Objectives: There are few reports about various prognostic factors associated with cancer specific survival (CSS) and disease-free survival (DFS) of patients with papillary thyroid carcinoma (PTC) in Korea. This study was performed to evaluate the clinicopathologic factors determining CCS and DFS of PTC patients in Korea.
Materials and Methods: The author applied the data from a retrospective analysis of 463 patients who underwent first thyroid surgery due to PTC in Asan medical center between 1996 and 1998. CSS and DFS were calculated by Kaplan-Meier method and various prognostic factors applied for Cox-proportional hazards model.
Results: Sixteen out of 463 patients (3%) were died from PTC in median 93 months of follow up. Sixty-six out of 441 patients (15%) without distant metastasis had recurrence. Distant metastasis and age were significantly associated with more cancer specific death (HR=60.4, p＜0.001 and HR=19.5, p=0.006). Gross and microscopic extrathyroidal extension were independent prognostic factors predicting poor CSS (HR=9.6, p=0.04 and HR=52.9, p＜0.001, respectively) and DFS (HR=3.2, p＜0.001 and HR=12.1, p＜0.001, respectively). Cervical lymph node metastasis and male gender were associated with more clinical recurrences without regard to CSS.
Conclusion: Independent prognostic factors correlated with CSS were distant metastasis, age and extrathyroidal extension, whereas extrathyroidal extension, cervical lymph node metastasis and gender were significantly associated with clinical recurrence.
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KEYWORD
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Thyroid cancer, Papillary carcinoma, Survival, Disease-free survival
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